منابع مشابه
cell free dna: a novel biomarker for clinical diagnosis
cell free dnas (cfdnas) are small fragments of genomic or mitochondrial dna releasing from cells into the blood stream. the presence of cfdna in the human circulatory system has been shown for the first time in 1948 however, the potential clinical applications of cfdna remained unknown until recent progress in detection and quantification of these molecules by sensitive methods. in this paper, ...
متن کاملCirculating cell-free DNA as a prognostic and predictive biomarker in non-small cell lung cancer
Circulating cell-free DNA (cfDNA), which can be obtained from plasma or serum by non-invasive procedures, has showed great potential to predict treatment response and survival for cancer patients. Several studies have assessed the prognostic and predictive value of cfDNA in non-small cell lung cancer (NSCLC). However, these studies were often small and reported varying results. To address this ...
متن کاملCell - free DNA: بیومارکر نوین تشخیص آزمایشگاهی
به انواع مختلف اسیدهای نوکلئیک آزاد در پلاسما شامل قطعات DNA ژنومی،DNA میتوکندریایی، DNA و mRNA های ویروسی و همچنین انواع miRNA اصطلاحا Cell–free nucleic acid گفته می شود. بخش مهمی از این اسیدهای نوکلئیک آزاد در پلاسما را Cell–free DNA (cfDNA) تشکیل می دهد. cfDNA به صورت قطعاتی با وزن مولکولی حدود KB 21-0.18 در سرم یا پلاسمای افراد سالم و افراد مبتلا به بسیاری از بیماری ها قابل تشخیص هستند. ...
متن کاملA New Biomarker for Hepatocellular Damage: Plasma Cell-Free DNA
Background: Accumulating evidence has suggested that cell-free DNA (cf-DNA) enters the circulation following cell apoptosis or necrosis. An increased level of cf-DNA fragments has been found in the blood of mice with drug-induced liver damage. We sought to determine the role of cf-DNA in hepatocellular damage. Methods: Plasma samples were collected from 204 patients with hepatitis. The patients...
متن کاملCirculating cell-free DNA content as blood based biomarker in endometrial cancer
Background Altered circulating cell-free DNA (cfDNA) levels are related to cancer development and aggressiveness. Up to now, very few studies have been performed for evaluating cfDNA content in endometrial cancer (EC). Methods First, we measured cfDNA release in blood serum of EC cancer patients collected before surgery and before the beginning of any treatment by SYBR Gold assay and correlat...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2020
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.934242